Cuba is a huge political issue in Florida because that’s where all the slave owning families fled. US basically can’t normalize relations with Cuba because any party that tries to do it would lose the Florida vote.

Meanwhile, Iran is basically their main enemy in the Middle East right now. Iran has close relations with Russia, it basically runs Iraq now, they also have good relations with Syria, and now starting to have diplomatic relations with the Saudis. It’s looking increasingly likely that Iran will become the dominant power in the region and will be able to push US out.