I wrote the research team and have skimmed the article. Dose regimen was 0.05mg/kg every other day. This would be about 0.25mg in an adult female human. Or about 0.25g of moderate potency cubensis. Half that or less of strong cubensis (PE/APE/etc).
That’s about what I used to microdose. I was very happy and content with life for the month I did it.
However, when I abruptly stopped, I entered the absolute worst depression I’ve ever had in my life and it almost killed me. This is anecdotal so take it with a grain of salt, but I’d say tapering off is absolutely necessary.
Was your dose frequency every other day?
I have a friend wanting to microdose and want her to be aware of your experience and possible withdrawal symptoms. The study used every other day which I would assume would minimize withdrawal considering psilocybin has a short half-life.
But I haven’t tried microing in years and when I did I only stuck with it for a week.
As far as withdrawal symptoms, there were no cravings or anything like that. Being an ex-alcoholic I know how those feel. Psilocybin has no physically addictive properties. I think the adjustment from being super happy all the time to ‘normal’ after quitting was a huge punch to the gut, but that doesn’t really qualify as a withdrawal symptom.
Ahh… I’ve gone through SSRI withdrawal and I thought maybe something similar could be happening because of the repeated dosing.
Did you get the “zaps” as I like to call them? I’ve gone through those as well. Turning your head and feeling a weird electric shock in the brain. So much fun.
This thread is making me realize how jacked up I am.
Yup. Was on venlafaxine and then duloxotine. Had to switch to Prozac and taper that.
It sucked.
Well, rest assured, nothing like that with shrooms.
Follow-up question: Has she considered or has she done a heroic dose as opposed to micro-dosing? You could be her ‘sitter’ while she does one. I find such an experience has vastly impactful benefits compared to micro-dosing. Plus side is you only need to do it once. You wake up ‘reset’ if that makes sense. My life was completely changed for the better from a single heroic dose.
I have sat her a few times. Not a heroic dose yet but an eighth on three separate occasions.
She’s a bit hard to get to disengage. So she misses a lot of the experience talking etc. Plus she’s on Suboxone which I think might be coloring the experience. But we went for a walk in a nature preserve last time so at least I got her out in nature.
I’ve taken heroic doses a number of times. The first time definitely changed my perspective on life in a major way. I think it can be beneficial for people and could be beneficial for her. Just need to find the space and time to do it.
I microdosed for about 6 months and didn’t have any negative effects after stopping personally, but I used a different dosing schedule. I dosed every three days. The idea for that is to have a microdose day, an afterglow day, and finally a baseline day before repeating. I found this helpful both for tolerance, and also so you can compare your mood and experience to baseline even while you’re still on the regimen.
Cool, thanks for the info.
In the study the found no tolerance build up. I think having a day between is probably part of it for sure.
Mine was every day, so that probably had a major impact.
This seems kind of silly to me. This is a drug that affects the brain, and that is nearly harmless at the microdose level. Just test on human volunteers. That way your results have useful clinical meaning. You can’t really ask the rats how they felt after the regimen.
They are, but placebo makes it difficult to measure.
This study proves more is going on then placebo and will surely help more funding go into human studies.
It’s certainly not silly. But I keep pet rats and I do find the methods used in animal studies often cruel. This one included.
But it’s not silly.
Yeah usually animal models are used because of danger to humans but we have plenty of evidence this substance is harmless.
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