I wrote the research team and have skimmed the article. Dose regimen was 0.05mg/kg every other day. This would be about 0.25mg in an adult female human. Or about 0.25g of moderate potency cubensis. Half that or less of strong cubensis (PE/APE/etc).

  • Neil@lemmy.ml
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    1 year ago

    That’s about what I used to microdose. I was very happy and content with life for the month I did it.

    However, when I abruptly stopped, I entered the absolute worst depression I’ve ever had in my life and it almost killed me. This is anecdotal so take it with a grain of salt, but I’d say tapering off is absolutely necessary.

    • treefrog@lemm.eeOP
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      1 year ago

      Was your dose frequency every other day?

      I have a friend wanting to microdose and want her to be aware of your experience and possible withdrawal symptoms. The study used every other day which I would assume would minimize withdrawal considering psilocybin has a short half-life.

      But I haven’t tried microing in years and when I did I only stuck with it for a week.

      • Neil@lemmy.ml
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        1 year ago

        As far as withdrawal symptoms, there were no cravings or anything like that. Being an ex-alcoholic I know how those feel. Psilocybin has no physically addictive properties. I think the adjustment from being super happy all the time to ‘normal’ after quitting was a huge punch to the gut, but that doesn’t really qualify as a withdrawal symptom.

        • treefrog@lemm.eeOP
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          1 year ago

          Ahh… I’ve gone through SSRI withdrawal and I thought maybe something similar could be happening because of the repeated dosing.

          • Neil@lemmy.ml
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            1 year ago

            Did you get the “zaps” as I like to call them? I’ve gone through those as well. Turning your head and feeling a weird electric shock in the brain. So much fun.

            This thread is making me realize how jacked up I am.

            • treefrog@lemm.eeOP
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              1 year ago

              Yup. Was on venlafaxine and then duloxotine. Had to switch to Prozac and taper that.

              It sucked.

              • Neil@lemmy.ml
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                1 year ago

                Well, rest assured, nothing like that with shrooms.

                Follow-up question: Has she considered or has she done a heroic dose as opposed to micro-dosing? You could be her ‘sitter’ while she does one. I find such an experience has vastly impactful benefits compared to micro-dosing. Plus side is you only need to do it once. You wake up ‘reset’ if that makes sense. My life was completely changed for the better from a single heroic dose.

                • treefrog@lemm.eeOP
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                  1 year ago

                  I have sat her a few times. Not a heroic dose yet but an eighth on three separate occasions.

                  She’s a bit hard to get to disengage. So she misses a lot of the experience talking etc. Plus she’s on Suboxone which I think might be coloring the experience. But we went for a walk in a nature preserve last time so at least I got her out in nature.

                  I’ve taken heroic doses a number of times. The first time definitely changed my perspective on life in a major way. I think it can be beneficial for people and could be beneficial for her. Just need to find the space and time to do it.

      • Ellatsu@lemmy.world
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        1 year ago

        I microdosed for about 6 months and didn’t have any negative effects after stopping personally, but I used a different dosing schedule. I dosed every three days. The idea for that is to have a microdose day, an afterglow day, and finally a baseline day before repeating. I found this helpful both for tolerance, and also so you can compare your mood and experience to baseline even while you’re still on the regimen.

        • treefrog@lemm.eeOP
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          1 year ago

          Cool, thanks for the info.

          In the study the found no tolerance build up. I think having a day between is probably part of it for sure.