I wrote the research team and have skimmed the article. Dose regimen was 0.05mg/kg every other day. This would be about 0.25mg in an adult female human. Or about 0.25g of moderate potency cubensis. Half that or less of strong cubensis (PE/APE/etc).

  • treefrog@lemm.eeOP
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    9 months ago

    Was your dose frequency every other day?

    I have a friend wanting to microdose and want her to be aware of your experience and possible withdrawal symptoms. The study used every other day which I would assume would minimize withdrawal considering psilocybin has a short half-life.

    But I haven’t tried microing in years and when I did I only stuck with it for a week.

    • Neil@lemmy.ml
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      9 months ago

      As far as withdrawal symptoms, there were no cravings or anything like that. Being an ex-alcoholic I know how those feel. Psilocybin has no physically addictive properties. I think the adjustment from being super happy all the time to ‘normal’ after quitting was a huge punch to the gut, but that doesn’t really qualify as a withdrawal symptom.

      • treefrog@lemm.eeOP
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        9 months ago

        Ahh… I’ve gone through SSRI withdrawal and I thought maybe something similar could be happening because of the repeated dosing.

        • Neil@lemmy.ml
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          9 months ago

          Did you get the “zaps” as I like to call them? I’ve gone through those as well. Turning your head and feeling a weird electric shock in the brain. So much fun.

          This thread is making me realize how jacked up I am.

          • treefrog@lemm.eeOP
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            9 months ago

            Yup. Was on venlafaxine and then duloxotine. Had to switch to Prozac and taper that.

            It sucked.

            • Neil@lemmy.ml
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              9 months ago

              Well, rest assured, nothing like that with shrooms.

              Follow-up question: Has she considered or has she done a heroic dose as opposed to micro-dosing? You could be her ‘sitter’ while she does one. I find such an experience has vastly impactful benefits compared to micro-dosing. Plus side is you only need to do it once. You wake up ‘reset’ if that makes sense. My life was completely changed for the better from a single heroic dose.

              • treefrog@lemm.eeOP
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                9 months ago

                I have sat her a few times. Not a heroic dose yet but an eighth on three separate occasions.

                She’s a bit hard to get to disengage. So she misses a lot of the experience talking etc. Plus she’s on Suboxone which I think might be coloring the experience. But we went for a walk in a nature preserve last time so at least I got her out in nature.

                I’ve taken heroic doses a number of times. The first time definitely changed my perspective on life in a major way. I think it can be beneficial for people and could be beneficial for her. Just need to find the space and time to do it.

    • Ellatsu@lemmy.world
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      9 months ago

      I microdosed for about 6 months and didn’t have any negative effects after stopping personally, but I used a different dosing schedule. I dosed every three days. The idea for that is to have a microdose day, an afterglow day, and finally a baseline day before repeating. I found this helpful both for tolerance, and also so you can compare your mood and experience to baseline even while you’re still on the regimen.

      • treefrog@lemm.eeOP
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        9 months ago

        Cool, thanks for the info.

        In the study the found no tolerance build up. I think having a day between is probably part of it for sure.