I mean those are pretty major things, especially if you’re part of one of the affected minorities. If I were trans I wouldn’t really want to work with a coworker who insists on misgendering me and makes a fuss out of me using the right bathroom.

If it doesn’t come up, it doesn’t come up. People can agree to disagree, also. But there are also cases where the disagreement is so fundamental that it makes it pretty hard to respect someone or even want to be in the same room as them.