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qBittorrent
SoulSeek: peer-to-peer file sharing application primarily used to exchange music. Direct download with no swarm.
nicotine+: FOSS client for the SoulSeek protocol
deleted by creator
MuWire: Gnutella over I2P, with swarm
Tribler: torrent over it’s own onion network
eMule/amule: as of 2022 eMule is still alive, specially for older films. It has 130-150k users at any time of the day, 75% of them from Italy, Spain and France. List of servers
DC++/linuxdcpp: Direct Connect protocol
DarkMX: closed source, unknown protocol, P2P over tor, with swarm
Fopnu: closed source, unknown protocol, P2P with swarm
MLDonkey: the Open Source eDonkey client
RetroShare