Ever since its appearance in Android Pie, I always consider 2 button navigation is a bad attempt by Google trying to play catch-up with the fad generated by the iPhone X. However, due to a bug with A13 QPR2 it had to be temporarily removed and many were not happy about this. So, 2 button navigation users, may I ask why do you prefer this method? To me it makes you do more for the same action whilst doesn’t save any screen space.
Tip I have is to adjust the angles to one that makes it feel most consistent to you for the up and down gestures. You can also set up long swipes too for where if you swipe a little further until you feel a haptics you can have it do stuff like make it show a mini quick tools so you don’t have to reach up and pull the status bar down to access them.
It’s pretty useful and you can have it behave differently for the left and right side so have lot of different actions available.