First off ask yourself “what suits my content the most?” This will be a key part of designing your stream layout as a layout that works for me might not work for you like different colors, xhat preferences, etc.

Then ask yourself, “any fancy features for my layout?”. I highly recommend plugins like gradients and audio visualizers (aka the lines things you see in trap music video and under my cam) since they make an amateur stream look pro.

The rest is up to you