Yeah definitely, the modlist authors, like the one for living Skyrim 4, for example, spent years with a group of closed beta testers to iron out mod conflicts and bugs and edited them out in xedit. Only downside is the modlist usually don’t have much leeway in plugin slots left over for you to install your own mods so you will have to esl-ify or merge your own mods (merge mapper on Nexus mods helps a ton in allowing you to pretty much merge anything)